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Marinobufagenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Marinobufagenin图片
CAS NO:470-42-8
规格:98%
分子量:400.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo.
CAS:470-42-8
分子式:C24H32O5
分子量:400.5
纯度:98%
存储:Store at -20°C

Background:

Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals. MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension. Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure. Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions.