您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > VPS34-IN1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
VPS34-IN1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VPS34-IN1图片
CAS NO:1383716-33-3
规格:98%
分子量:425.91
包装与价格:
包装价格(元)
5mg电议
25mg电议
100mg电议

产品介绍
Vps34 inhibitor
CAS:1383716-33-3
分子式:C21H24ClN7O
分子量:425.91
纯度:98%
存储:Store at -20°C

Background:

IC50: 25 nM


VPS34-IN1 is a Vps34 inhibitor.


The vacuolar protein sorting 34 (Vps34) class III phosphoinositide 3-kinase (PI3K) phosphorylates phosphatidylinositol (PtdIns) to generate PtdIns(3)P that regulates membrane trafficking processes through its ability to recruit a subset of proteins possessing PtdIns(3)P-binding phox homology (PX) and FYVE domains.


In vitro: VPS34-IN1 was identified to be able to inhibit in-vitro Vps34, but did not significantly inhibit the activity of tested 340 protein kinases or 25 lipid kinases that include all isoforms of class I and class II PI3Ks. Treatment of VPS34-IN1 to cells dose-dependently induced a quick dispersal of a specific PtdIns(3)P-binding probe, without altering the ability of class I PI3K to regulate Akt. Moreover, VPS34-IN1 could also induce a quick