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Calpeptin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calpeptin图片
CAS NO:117591-20-5
规格:98%
分子量:362.47
包装与价格:
包装价格(元)
10mg电议
50mg电议
500mg电议
1g电议

产品介绍
Ca2+-dependent protease,calpain inhibitor
CAS:117591-20-5
分子式:C20H30N2O4
分子量:362.47
纯度:98%
存储:Store at -20°C

Background:

IC50: 5 nM for human calpain 1


Calpeptin is a calpain inhibitor.


As a calcium-dependent intracellular cysteine protease, calpain plays an key role in various cellular processes including cell differentiation, growth and apoptosis. In rheumatoid arthritis patients, over-expression of calpains are observed in arthritic synovial fluid and are thought to play critical roles in various cellular processes.


In vitro: Calpeptin reduced production of TGF-b1, IL-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. Calpeptin also reduced both angiopoietin-1-dependent migration and IL-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of Calpeptin on pulmonary fibrosis [1].


In vivo: The preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. Histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. Calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. Results showed that calpeptin decreased the expression of IL-6, TGF-b1, angiopoietin-1 and collagen type Ia1 mRNA in mouse lung tissues [1].


Clinical trial: N/A


Reference:
[1] Tabata C,Tabata R,Nakano T.  The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Clin Exp Immunol.2010 Dec;162(3):560-7.