连接片段 1 (CS-1) 是位于纤维连接蛋白的 III 型同源连接段 (IIIC) 中的细胞连接域。Fibronectin CS1 Peptide 缺乏 Arg-Gly-Asp 结构域,在自发和实验性转移模型中能有效抑制肿瘤转移。
CAS:136466-51-8
分子式:C38H64N8O15
分子量:872.96
纯度:98%
存储:Store at -20°C
Background:
The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. Fibronectin CS1 Peptide lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models[1].
[1]. Saiki I, et al. Inhibition of lung metastasis by synthetic and recombinant fragments of human fibronectin with functional domains. Jpn J Cancer Res. 1990 Oct;81(10):1003-11.