CP-96486是一种口服有效的白三烯D4(LTD4)/血小板活化因子(PAF)受体拮抗剂，Ki值分别为20和24nM。
CAS：139401-45-9
分子式：C31H23ClN4O
分子量：502.99
纯度：98%
存储：Store at -20°C

Background:

CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.

CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki’s of 20 and 24 nM respectively[1].

CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50’s of 0.27 and 0.26 mg/kg p.o. respectively[1].

[1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists.