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N-desmethyl Bendamustine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Bendamustine图片
CAS NO:41515-13-3
规格:98%
分子量:344.2
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine.
CAS:41515-13-3
分子式:C15H19Cl2N3O2
分子量:344.2
纯度:98%
存储:Store at -20°C

Background:

N-desmethyl Bendamustine is an active metabolite of the DNA alkylating agent bendamustine . N-desmethyl Bendamustine is formed through demethylation of the benzimidazole ring in bendamustine by the cytochrome P450 (CYP) isoform CYP1A2. It inhibits proliferation of non-cancerous peripheral blood leukocytes (PBLs; IC50 = 45 µM) and SU-DHL-1, SU-DHL-9, and Daudi lymphoma cells (IC50s = 270, 170, and 120 µM, respectively).