3-Methylxanthine是黄嘌呤衍生物,能够抑制GMP,在豚鼠分离的气管肌肉中测得其IC50值为920μM。
CAS:1076-22-8
分子式:C6H6N4O2
分子量:166.14
纯度:98%
存储:Store at -20°C
Background:
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.
[1]. Tanaka H, et al. Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin Exp Pharmacol Physiol. 1991 Mar;18(3):163-8. [2]. Yamamoto K, et al. Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biol Pharm Bull. 1996 Jun;19(6):869-72.