Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.
CAS：4825-86-9
分子式：C20H19NO6
分子量：369.4
纯度：98%
存储：Store at -20°C

Background:

Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods.[1],[2] Ochratoxin A is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas.[1],[2] OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion.[3],[4],[5] OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 μg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.[3]
Reference:
[1]. Richard, J.L. Some major mycotoxins and their mycotoxicoses - An overview. Int. J. Food Microbiol. 119(1-2), 3-10 (2007).
[2]. Bennett, J.W., and Klich, M. Mycotoxins. Clin.Microbiol.Rev. 16(3), 497-516 (2003).
[3]. Knasmüller, S., Cavin, C., Chakraborty, A., et al. Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human-derived liver (HepG2) cells: Implications for risk assessment. Nutrition and Cancer 50(2), 190-197 (2004).
[4]. O'Brien, E., Prietz, A., and Dietrich, D.R. Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system. Birth Defects Res.B Dev.Reprod.Toxicol. 74(5), 417-423 (2005).
[5]. Mally, A., Keim-Heusler, H., Amberg, A., et al. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicology and Applied Pharmacology 206(1), 43-53 (2005).