Cutamesine(SA4503;AGY-94806)isaselectivesigma1receptor(σ1R)agonist;highaffinityforthesigma1receptorsubtypelabeledby(+)-[3H]pentazocine(IC50=17.4±1.9nM);100-foldlessaffinityforthesigma2receptor.
CAS：165377-43-5
分子式：C23H32N2O2
分子量：368.51
纯度：98%
存储：Store at -20°C

Background:

Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor.

[1]. Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9. [2]. Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40. [3]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8.