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4-hydroxy Alternariol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-hydroxy Alternariol图片
CAS NO:959417-21-1
规格:98%
分子量:274.2
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism.
CAS:959417-21-1
分子式:C14H10O6
分子量:274.2
纯度:98%
存储:Store at -20°C

Background:

4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 uM under cell-free conditions.