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Prazosin HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prazosin HCl图片
CAS NO:19237-84-4
包装:100mg
规格:98%
市场价:881元
分子量:419.86

产品介绍
α1 and α2B-adrenoceptor antagonist
CAS:19237-84-4
分子式:C19H21N5O4.HCl
分子量:419.86
纯度:98%
存储:Store at -20°C

Background:

Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.Target: Adrenergic ReceptorPrazosin hydrochloride, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, Prazosin (hydrochloride) is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, Prazosin (hydrochloride) is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors.Prazosin hydrochloride is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when Prazosin (hydrochloride) is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when Prazosin (hydrochloride) is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.


参考文献:
[1]. Day HE, et al. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 Jul;13(2):115-39.
[2]. Yu CX, et al. Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. Neurosci Lett. 2000 Mar 24;282(3):161-4.