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CHPG Sodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CHPG Sodium salt图片
CAS NO:1303993-73-8
规格:98%
分子量:223.59
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
mGlu5 agonist
CAS:1303993-73-8
分子式:C8H7ClNNaO3
分子量:223.59
纯度:98%
存储:Store at -20°C

Background:

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].


CHPG sodium salt (10-500?μM; 24?hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1]. CHPG sodium salt (0.5?mM; 30?mins ) protects BV2 cells against SO2-induced apoptosis[1]. CHPG sodium salt (0.5 mM; 30?mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].


CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].


参考文献:
[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.
[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.