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ACS 67
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACS 67图片
CAS NO:1088434-86-9
规格:98%
分子量:598.8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
analog of latanoprost (free acid),prostaglandin (PG) analog
CAS:1088434-86-9
分子式:C32H38O5S3
分子量:598.8
纯度:98%
存储:Store at -20°C

Background:

ACS 67 is an analog of latanoprost acid.


Latanoprost, an F-series prostaglandin (PG) analog, has been approved for use as an ocular hypotensive drug for the treatment of glaucoma clinically. Latanoprost is an isopropyl ester, a prodrug form which is converted to free latanoprost acid by endogenous esterase enzymes.


In vitro: In previous study, ACS 67 was found to be able to increase the reduced glutathione levels in normotensive pigmented rabbits significantly after single administration in a dose-dependent manner. Furthermore, in glaucomatous pigmented rabbits after repeated 5-day administration, ACS 67 could also increase the GSH levels when compared with latanoprost. In addition, it was found that ACS 67 could significantly increase the cGMP levels in glaucomatous pigmented rabbits and these data with the combination supported that the increase of cGMP was due to the sulfurated moiety of ACS 67. Moreover, the tolerability was measured in New Zealand albino rabbits at three different concentrations of ACS 67, and results indicated that ACS 67 was very well tolerated in Draize test [1].


In vivo: So far, there in no animal in vivo data reported.


Clinical trial: Up to now, ACS 67 is still in the preclinical development stage.


Reference:
[1] E.  Perrino, C. Uliva, C. Lanzi, et al. New prostaglandin derivative for glaucoma treatment. Bioorganic & Medicinal Chemistry Letters 19, 1639-1642 (2009).