Isavuconazonium is a water-soluble prodrug form of the azole antifungal isavuconazole (ISA).
CAS：946075-13-4
分子式：C35H35F2N8O5S.HO4S
分子量：814.8
纯度：98%
存储：Store at -20°C

Background:

Isavuconazonium is a water-soluble prodrug form of the azole antifungal isavuconazole (ISA). Oral administration of isavuconazonium increases survival in rat models of azole-susceptible and -resistant A. fumigatus infection when administered at doses ranging from 0.25 to 512 mg/kg per day (ISA-equivalent = 0.12-245.8 mg/kg per day). Isavuconazonium reduces fungal burden and organism-mediated pulmonary injury and increases survival in a rabbit model of experimental invasive pulmonary aspergillosis when administered at ISA-equivalent doses ranging from 40 to 60 mg/kg.