您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Estetrol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Estetrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Estetrol图片
CAS NO:15183-37-6
规格:98%
分子量:304.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An estrogen steroid hormone
CAS:15183-37-6
分子式:C18H24O4
分子量:304.4
纯度:98%
存储:Store at -20°C

Background:

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).[1],[2] In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.[1],[2]


Reference:


[1]. Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E. Estetrol review: Profile and potential clinical applications Climacteric. 11(Suppl 1), 47-58 (2008).
[2]. Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton Front.Endocrinol.(Lausanne) 5(80), 1-8 (2014).