A potent and selective PDGFR family inhibitor
CAS：1351522-04-7
分子式：C31H42N6O4
分子量：562.7
纯度：98%
存储：Store at -20°C

Background:

AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Its IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. AC710 is now a preclinical development candidate.

REFERENCES:

Liu *??, Brian T. Campbell ??, Mark W. Holladay ??, Julia M. Ford Pulido ??, Helen Hua ??, Dana Gitnick , Michael F. Gardner , Joyce James , Mike A. Breider , Daniel Brigham ??, Barbara Belli ??, Robert C. Armstrong ??, and Daniel K. Treiber. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med. Chem. Lett., 2012, 3 (12), pp 997?–1002