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Sulprostone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulprostone图片
CAS NO:60325-46-4
规格:98%
分子量:465.56
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
EP3 and EP1 receptor agonist
CAS:60325-46-4
分子式:C23H31NO7S
分子量:465.56
纯度:98%
存储:Store at -20°C

Background:

Sulprostone is a metabolism resistant synthetic analog of PGE2.[1] It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 μM for the inhibition of PGE2 binding.[2],[3] Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity.[4],[5]


Reference:
[1]. Schaaf, T.K., Bindra, J.S., Eggler, J.F., et al. N-(methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-selective, uterine stimulants. Journal of Medicinal Chemistry 24, 1353-1359 (1981).
[2]. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000).
[3]. Negishi, M., Harazono, A., Sugimoto, Y., et al. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. Prostaglandins 48, 275-283 (1994).
[4]. Schillinger, E., Prior, G., Speckenbach, A., et al. Receptor binding in various tissues of PGE2, and sulprostone, a novel PGE2-derivative. Prostaglandins 18, 293-302 (1979).
[5]. Krishna, U., Gupta, A.N., Ma, H.K., et al. Randomized comparison of different prostaglandin analogues and laminaria tent for preoperative cervical dilation. Contraception 34, 237-251 (1986).