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CGS 9343B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CGS 9343B图片
CAS NO:109826-27-9
包装:10mg
规格:98%
市场价:3322元
分子量:544.61

产品介绍
Calmodulin antagonist
CAS:109826-27-9
分子式:C26H28N4O2.C4H4O4
分子量:544.61
纯度:98%
存储:Store at -20°C

Background:

Zaldaride maleate (CGS-9343B) is a potent and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3].


参考文献:
[1]. Norman JA, et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity. Mol Pharmacol. 1987 May;31(5):535-40.
[2]. Neuhaus R, et al. Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor. Eur J Pharmacol. 1992 Jun 5;226(2):183-5.
[3]. Li L, et al. Calmodulin regulates the transcriptional activity of estrogen receptors. Selective inhibition of calmodulin function in subcellular compartments. J Biol Chem. 2003 Jan 10;278(2):1195-200.