BMS493 is an inverse agonist of pan-retinoic acid receptors (pan-RARs). BMS493 has been shown to increase nuclear corepressor (NCoR) interaction with RARs. In cellular culture, pretreatment of BMS493 on MEPM cells blocked atRA-induced apoptotic indexes. BMS493 completely inhibited atRA-induced Sub-G1 fraction, DNA fragmentation, and caspase-3 activation. References: Wilde S, Logan MP. Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick. J Vis Exp. 2016 Nov 17;(117). doi: 10.3791/54618. PubMed PMID: 27911385; PubMed Central PMCID: PMC5226245.

纯度：≥98%

CAS：215030-90-3