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SHIN1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SHIN1图片
CAS NO:2146095-85-2
规格:98%
分子量:400.47
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
SHIN1是人丝氨酸羟甲基转移酶1和2(SHMT1/2)抑制剂,体外实验中的其IC50值分别为5和13nM。
CAS:2146095-85-2
分子式:C24H24N4O2
分子量:400.47
纯度:98%
存储:Store at -20°C

Background:

SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.


SHIN1 inhibits human SHIN1 SHMT1/2 with IC50s of 5 and 13 nM, respectively in an in vitro assay. SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells with an IC50 of 10 nM. SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates[1].



[1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.