Background:

RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.

RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine. RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect[1].

[1]. Iwata N, et al. Pharmacology of the new reversible inhibitor of monoamine oxidase A, RS-8359. Int Clin Psychopharmacol. 1997 Sep;12 Suppl 5:S3-10.