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GSK-J5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK-J5(hydrochloride)图片
CAS NO:1797983-32-4
规格:98%
分子量:454
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.
CAS:1797983-32-4
分子式:C24H27N5O2.HCl
分子量:454
纯度:98%
存储:Store at -20°C

Background:

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 >100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.