Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid.
CAS：474-74-8
分子式：C26H43NO4
分子量：433.6
纯度：98%
存储：Store at -20°C

Background:

Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid.[1] It is increased in livers of mice that are fed diets supplemented with ursodeoxycholic acid.[2] Glycolithocholic acid levels are decreased in lean mice treated with obestatin.[3] Serum glycolithocholic acid levels increase with age in children.[4]

Reference:
[1]. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).
[2]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[3]. Cowan, E., Kimar, P., Burch, K.J., et al. Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics. Metabolomics 12(124), (2016).
[4]. Semba, R.D., Gonzalez-Freier, M., Moaddel, R., et al. Environmental enteric dysfunction is associated with altered bile acid metabolism. J. Pediatr. Gastenterol. Nutr. 64(4), 536-540 (2017).

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