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4-oxo Docosahexaenoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-oxo Docosahexaenoic Acid图片
CAS NO:845673-74-7
规格:98%
分子量:342.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议
250ug电议

产品介绍
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity.
CAS:845673-74-7
分子式:C22H30O3
分子量:342.5
纯度:98%
存储:Store at -20°C

Background:

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.