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12-epi Leukotriene B4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
12-epi Leukotriene B4图片
CAS NO:83709-73-3
规格:98%
分子量:336.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes.
CAS:83709-73-3
分子式:C20H32O4
分子量:336.5
纯度:98%
存储:Store at -20°C

Background:

Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor.