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Lipoxin B4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lipoxin B4图片
CAS NO:98049-69-5
规格:98%
分子量:352.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes.
CAS:98049-69-5
分子式:C20H32O5
分子量:352.5
纯度:98%
存储:Store at -20°C

Background:

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.


参考文献:
[1]. Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B Proc. Nat. Acad. Sci. USA 83(7), 1983-1987 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells Journal of Immunology 156, 2264-2272 (1996).