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Forodesine hydrochloride(BCX-1777)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Forodesine hydrochloride(BCX-1777)图片
CAS NO:284490-13-7
规格:98%
分子量:302.71
包装与价格:
包装价格(元)
1000ug电议
2500ug电议
5mg电议

产品介绍
Forodesinehydrochloride是有效,可口服的嘌呤核苷磷酸化酶PNP抑制剂,其中IC50范围为0.48至1.57nM。
CAS:284490-13-7
分子式:C11H15ClN4O4
分子量:302.71
纯度:98%
存储:Store at -20°C

Background:

Forodesine hydrochloride is a potent and oral purine nucleoside phosphorylase (PNP) inhibitor with IC50s ranging from 0.48 to 1.57 nM.




[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90. [2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5. [3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895. [4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.