Fradafiban是一种非肽血小板糖蛋白IIb/IIIa复合体拮抗剂，其与人血小板GPIIb/IIIa复合体结合，Kd值为148nM。
CAS：148396-36-5
分子式：C20H21N3O4
分子量：367.4
纯度：98%
存储：Store at -20°C

Background:

Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.

Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1].

Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].

[1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.