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Emicerfont(GW876008)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emicerfont(GW876008)图片
CAS NO:786701-13-1
规格:98%
分子量:404.46
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Emicerfont是一个促肾上腺皮质激素释放因子1型(CRF1)受体拮抗剂,其IC50值为66nM。
CAS:786701-13-1
分子式:C22H24N6O2
分子量:404.46
纯度:98%
存储:Store at -20°C

Background:

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.


Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].


At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].


[1]. Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.