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Sphinganine-1-phosphate(d18:0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sphinganine-1-phosphate(d18:0)图片
CAS NO:19794-97-9
规格:98%
分子量:381.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids.
CAS:19794-97-9
分子式:C18H40NO5P
分子量:381.5
纯度:98%
存储:Store at -20°C

Background:

Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.