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DDD85646
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DDD85646图片
CAS NO:1215010-55-1
规格:98%
分子量:495.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T.
CAS:1215010-55-1
分子式:C21H24Cl2N6O2S
分子量:495.4
纯度:98%
存储:Store at -20°C

Background:

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM.1 T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT.[1] It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).


Reference:
1. Frearson, J.A., Brand, S., McElroy, S.P., et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature 464(7829), 728-732 (2010).