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C22 Ceramide(d18:1/22:0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C22 Ceramide(d18:1/22:0)图片
CAS NO:27888-44-4
规格:98%
分子量:622.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
C-22 ceramide is an endogenous bioactive sphingolipid.
CAS:27888-44-4
分子式:C40H79NO3
分子量:622.1
纯度:98%
存储:Store at -20°C

Background:

C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.[1] C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.[2]


Reference:
[1]. Stiban, J., and Perera, M. Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis. Biochim. Biophys. Acta 1848(2), 561-567 (2015).
[2]. Kim, H.E., Grant, A.R., Simic, M.S., et al. Lipid biosynthesis coordinates a mitochondrial-to-cytosolic stress response. Cell 166(6), 1539-1552 (2016).