ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme).
CAS：1502027-70-4
分子式：C16H24ClN3O5
分子量：373.8
纯度：98%
存储：Store at -20°C

Background:

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).