Tyk2-IN-8 (compound 10) 是一种选择性的 TYK2 抑制剂，结合到 TYK2 催化活性的 JH1 结构域，IC50 值为 17 nM，用于治疗用于治疗银屑病。
CAS：2127109-84-4
分子式：C20H17N9
分子量：383.41
纯度：98%
存储：Store at -20°C

Background:

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1]. IC50: 17 nM (TYK2 JH1)[1]

Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].

[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.