TH287盐酸盐是MTH1 (NUDT1)高效选择性抑制剂，IC50值0.8nM，对MTH2, NUDT5, NUDT12, NUDT14等抑制力弱。
CAS：1638211-05-8
分子式：C11H11Cl3N4
分子量：305.59
纯度：98%
存储：Store at -20°C

Background:

TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.

[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.