您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > BMS-929075
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BMS-929075
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1217338-97-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
50mg电议
500mg电议

产品介绍

BMS-929075 is a HCV NS5B Replicase Palm Site Allosteric Inhibitor. BMS-929075 exhibited a favorable cytotoxicity window. BMS-929075 demonstrated efficacy in a triple combination regimen in HCV replicon cells, and exhibited consistently high orally bioavailable bioavailability and pharmacokinetic parameters across preclinical animal species. The human PK properties from the Phase I clinical studies of BMS-929075 were better than anticipated and suggested promising potential for QD administration. References: Yeung KS, Beno BR, Parcella K, Bender JA, Grant-Young KA, Nickel A, Gunaga P, Anjanappa P, Bora RO, Selvakumar K, Rigat K, Wang YK, Liu M, Lemm JA, Mosure K, Sheriff S, Wan C, Witmer M, Kish K, Hanumegowda UM, Zhuo X, Shu YZ, Parker D, Haskell R, Ng A, Gao Q, Colston E, Raybon J, Grasela DM, Santone KS, Gao M, Meanwell NA, Sinz MW, Soars MG, Knipe JO, Roberts SB, Kadow JF. Discovery of an HCV NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem. 2017 Apr 21. doi: 10.1021/acs.jmedchem.7b00328. [Epub ahead of print] PubMed PMID: 28430437.

纯度:≥98%

CAS:1217338-97-0