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L-902,688
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-902,688图片
CAS NO:634193-54-7
规格:98%
分子量:419.5
包装与价格:
包装价格(元)
10mg电议
500ug电议
1mg电议
5mg电议

产品介绍
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4.
CAS:634193-54-7
分子式:C21H27F2N5O2
分子量:419.5
纯度:98%
存储:Store at -20°C

Background:

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.