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Emtricitabine S-oxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emtricitabine S-oxide图片
CAS NO:152128-77-3
规格:98%
分子量:263.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Emtricitabine S-oxide is a potential impurity found in commercial preparations of emtricitabine.
CAS:152128-77-3
分子式:C8H10FN3O4S
分子量:263.2
纯度:98%
存储:Store at -20°C

Background:

Emtricitabine S-oxide (Emtricitabine sulfoxide) is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.


Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1].


参考文献:
[1]. A Prakash, et al. Forced degradation study of emtricitabine for evaluation of genotoxic impurity in active pharmaceutical ingredient's (API) shelf life. World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(7), 1909-1919.