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Peimine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Peimine图片
CAS NO:23496-41-5
包装:20mg
规格:98%
市场价:1746元
分子量:431.65

产品介绍
Extracted from Fritillaria;Suitability:Methanol,ethanol,chloroform;Store the product in sealed,cool and dry condition
CAS:23496-41-5
分子式:C27H45NO3
分子量:431.65
纯度:98%
存储:Store at -20°C

Background:

Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.


参考文献:
[1]. Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.