Hydroxy-?α-?sanshool 是从胡椒中分离到的烷基酰胺，为 TRPA1 的共价激动剂和 TRPV1 的非共价激动剂，EC50 值分别为 69 和 1.1 ?M。
CAS：83883-10-7
分子式：C16H25NO2
分子量：263.38
纯度：98%
存储：Store at -20°C

Background:

Hydroxy-?α-?sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively[1]. EC50: 69 µM (TRPA1), 1.1 µM (TRPV1)[1]

[1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.