SR10067是有效的、选择性的、能透过大脑的Rev-Erbα/β的激动剂，其对Rev-Erbβ和Rev-Erbα的IC50值分别为160nM和170nM。SR10067具有抗焦虑活性。
CAS：1380548-02-6
分子式：C31H31NO3
分子量：465.58
纯度：98%
存储：Store at -20°C

Background:

SR10067 is a potent, selective and brain penetrant Rev-Erbα/β agonist, with IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively. SR10067 has anxiolytic activity[1][2]. IC50: 160 nM (Rev-Erbβ), 170 nM (Rev-Erbα)[1].

[1]. Banerjee S, et al. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat Commun. 2014 Dec 23;5:5759. doi: 10.1038/ncomms6759. [2]. Thevis M, et al. Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun Mass Spectrom. 2016 Mar 15;30(5):635-51.