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A-196
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A-196图片
CAS NO:1982372-88-2
规格:98%
分子量:359.25
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
A-196是有效的选择性SUV420H1和SUV420H2化学抑制剂,在多种细胞系中抑制H4K20me二甲基化和三甲基化。
CAS:1982372-88-2
分子式:C18H16Cl2N4
分子量:359.25
纯度:98%
存储:Store at -20°C

Background:

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50< 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate ’Lys-20’ of histone H4.