Halofantrinehydrochloride(SKF-102886)是一种通过抑制人ERG通道来延迟整流钾电流的阻滞剂,是一种有效的抗疟疾药。
CAS:36167-63-2
分子式:C26H31Cl3F3NO
分子量:536.88
纯度:98%
存储:Store at -20°C
Background:
Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound[1][2].
[1]. Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec;36(6):585-91. [2]. Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000) Traebert.