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IFN alpha-IFNAR-IN-1(IFN-alpha and IFNAR interaction inhibitor)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IFN alpha-IFNAR-IN-1(IFN-alpha and IFNAR interaction inhibitor)图片
CAS NO:844882-93-5
规格:98%
分子量:279.4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
IFNalpha-IFNAR-IN-1是IFNalpha和其受体IFNAR相互作用抑制剂,EC50值2-8uM。
CAS:844882-93-5
分子式:C18H17NS
分子量:279.4
纯度:98%
存储:Store at -20°C

Background:

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].




[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.