PGD2-IN-1是DP受体拮抗剂,来自专利专利WO2006044732A2，化合物实例15(d)，IC50值为0.3nM。
CAS：885066-67-1
分子式：C23H23Cl2N3O3
分子量：460.35
纯度：98%
存储：Store at -20°C

Background:

PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasal congestion[1].

[1]. Patent: WO/2006/044732A2 [2]. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.