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MSDC-0160
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MSDC-0160图片
CAS NO:146062-49-9
规格:98%
分子量:370.42
包装与价格:
包装价格(元)
2mg电议
10mg电议

产品介绍
mTOT-modulating insulin sensitizer
CAS:146062-49-9
分子式:C19 H18 N2 O4 S
分子量:370.42
纯度:98%
存储:Store at -20°C

Background:

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1].


MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator–activated receptor-γ (PPAR-γ)-dependent side effects. Co-incubation of islets with MSDC-0160 and IGF-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. MSDC-0160 at 50μM alone also prevents the loss of insulin content significantly. Besides that, treatment of MSDC-0160 increases the phosphorylation of AMPK and reduces mTOR phosphorylation. Moreover, MSDC-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. In addition, MSDC-0160 exerts prevention of nuclear translocation with β-catenin localized on the cell membrane or cytoplasm in human β-cells [1].


参考文献:
[1] Rohatgi N, Aly H, Marshall C A, et al. Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. PloS one, 2013, 8(5): e62012.