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HOE 140
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HOE 140图片
CAS NO:130308-48-4
包装:500ug
规格:98%
市场价:1646元
分子量:1304.52

产品介绍
Potent and selective bradykinin B2 receptor antagonist
CAS:130308-48-4
分子式:C59H89N19O13S
分子量:1304.52
纯度:98%
存储:Store at -20°C

Background:

Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.


参考文献:
[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.
[2]. George J, et al. Locally Mediated Analgesic Effect of Bradykinin Type 2 Receptor Antagonist HOE 140 During Acute Inflammatory Pain in Rats. J Burn Care Res. 2014 Jan 21.
[3]. Ferreira AP, et al. HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice. Psychopharmacology (Berl). 2014 May;231(9):1935-48.