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FGIN-1-27
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FGIN-1-27图片
CAS NO:142720-24-9
规格:98%
分子量:436.61
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
high affinity agonist of the translocator protein (TSPO,peripheral benzodiazepine receptor)
CAS:142720-24-9
分子式:C28H37FN2O
分子量:436.61
纯度:98%
存储:Store at -20°C

Background:

FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]


Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).