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Pantoprazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pantoprazole图片
CAS NO:102625-70-7
规格:98%
分子量:383.37
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
H+/K+-ATPase inhibitor
CAS:102625-70-7
分子式:C16H15F2N3O4S
分子量:383.37
纯度:98%
存储:Store at -20°C

Background:

Pantoprazole is an inhibitor of H+/K+-ATPase [1].


Pantoprazole inhibits the activity of H+/K+-ATPase proton pumb in the parietal cells of gastric mucosa. This inhibition affects the acid secretion and thus, pantoprazole are used as drugs for the treatment of various acid-related disorders. Pantoprazole is activated slowly. The activated sulfonamide of pantoprazole binds to Cys813 and Cys822 of the pumb and inhibits acid secretion selectively. Pantoprazole inhibited lysosomal acidification with IC50 value of 194 μM. The pKa values of pantoprazole are 3.83 (pKa1) and 0.11 (pKa2). Besides that, pantoprazole also shows antibacterial effects on Helicobacter pylori [1, 2].


参考文献:
[1] Jungnickel P W.  Pantoprazole: a new proton pump inhibitor. Clinical therapeutics, 2000, 22(11): 1268-1293.
[2] Sachs G, Shin J M, Howden C W.  Review article: the clinical pharmacology of proton pump inhibitors. Alimentary pharmacology & therapeutics, 2006, 23(s2): 2-8.