Urocanicacid是皮肤中的主要光线受体,天然以反式尿刊酸存在。
CAS:104-98-3
分子式:C6H6N2O2
分子量:138.12
纯度:98%
存储:Store at -20°C
Background:
Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).
Urocanic acid (UCA) is formed in the upper layers of the epidermis where filaggrin, a histidine-rich filamentous protein produced after caspase-14 cleavage of profilaggrin, is broken down by proteinases into component amino acids[1].
[1]. Gibbs NK, et al. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci. 2008 Jun;7(6):655-67.